2024
RNA: The Unsuspected Conductor in the Orchestra of Macromolecular Crowding
Zacco E, Broglia L, Kurihara M, Monti M, Gustincich S, Pastore A, Plath K, Nagakawa S, Cerase A, Sanchez de Groot N and Tartaglia GG.
RNA: The Unsuspected Conductor in the Orchestra of Macromolecular Crowding.
(2024) Chem Reviews, 124:4734-4777.
Associating growth factor secretions and transcriptomes of single cells in nanovials using SEC-seq
Udani S, Langerman J, Koo D, Baghdasarian S, Cheng B, Kang S, Soemardy C, de Rutte J, Plath K* and Di Carlo D*. (2024).
Associating growth factor secretions and transcriptomes of single cells in nanovials using SEC-seq.
Nature Nanotechnology. 19:354-363. *corresponding authors.
Optimization of RNA Pepper Sensors for the Detection of Arbitrary RNA Targets
Tang AA, Afasizheva A, Cano CT, Plath K, Black D and Franco E. (2024).
Optimization of RNA Pepper Sensors for the Detection of Arbitrary RNA Targets.
ACS Synth Biology, 13:498-508.
XIST directly regulates X-linked and autosomal genes in naïve human pluripotent cells
Dror I, Chitiashvili T, Tan SYX, Cano CT, Sahakyan A, Markaki Y, Chronis C, Collier A, Deng W, Liang G, Sun Y, Afasizheva A, Miller J, Xiao W, Black DL, Ding F and Plath K. (2024).
XIST directly regulates X-linked and autosomal genes in naïve human pluripotent cells.
Cell, 187:110-129.
2023
Nutrient regulation of development and cell fate decisions
Tu W, Christofk H* and Plath K* (2023).
Nutrient regulation of development and cell fate decisions.
Development, 150: dev199961. * corresponding authors.
H3K36 methylation maintains cell identity by regulating opposing lineage programmes
Hoetker MS, Yagi M, Di Stefano B, Langerman J, Cristea S, Wong LP, Huebner AJ, Charlton J, Deng W, Haggerty C, Sadreyev RI, Meissner A, Michor F, Plath K and Hochedlinger K. (2023).
H3K36 methylation maintains cell identity by regulating opposing lineage programmes.
Nature Cell Biology, 25:1121-1134.
ZFP36-mediated mRNA decay regulates metabolism
Cicchetto AC, Jacobson EC, Sunshine H, Wilde BR, Krall AS, Jarrett KE, Sedgeman L, Turner M, Plath K, Iruela-Arispe ML, de Aguiar Vallim TQ and Christofk HR. (2023).
ZFP36-mediated mRNA decay regulates metabolism.
Cell Reports, 42:112411.
2022
Essential roles for Oct4:Sox2 binding in establishing but not maintaining active and silent states of dynamically regulated genes in pluripotent cells
Lo JH, Edwards M, Langerman J, Sridharan R, Plath K and Smale ST. (2022).
Essential roles for Oct4:Sox2 binding in establishing but not maintaining active and silent states of dynamically regulated genes in pluripotent cells.
Genes & Development, DOI: 10.1101/gad.350113.122.
High-field asymmetric waveform ion mobility spectrometry interface enhances parallel reaction monitoring on an Orbitrap mass spectrometer
Deng W, Sha J, Fanglei X; Yasaman JA, Plath K and Wohlschlegel J. (2022).
High-field asymmetric waveform ion mobility spectrometry interface enhances parallel reaction monitoring on an Orbitrap mass spectrometer.
Analytical Chemistry, 94:15939-15947.
TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids
Watanabe M, Buth JE, Haney JR, Vishlaghi N, Turcios F, Elahi LS, Gu W, Pearson CA, Kurdian A, Baliaouri NV, Collier AJ, Miranda OA, Dunn N, Chen D, Sabri S, Torre-Ubieta L, Clark AT, Plath K, Christofk HR, Kornblum HI, Gandal MJ, Novitch BG. (2022).
TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids.
Stem Cell Reports. S2213-6711(22)00422-2. doi: 10.1016/j.stemcr.2022.08.013.
A lifelong duty: how Xist maintains the inactive X chromosome
Jacobson EC, Pandya-Jones A, and Plath K. 2022.
A lifelong duty: how Xist maintains the inactive X chromosome.
Curr Opin Genet Dev, 75:101927. doi: 10.1016/j.gde.2022.101927.
FGFR3 is Expressed by Human Primordial Germ Cells and is Repressed after Meiotic Initiation to Form Primordial Oocytes
Chitiashvili T, Hsu F, Dror I, Plath K & Clark A (2022).
FGFR3 is Expressed by Human Primordial Germ Cells and is Repressed after Meiotic Initiation to Form Primordial Oocytes.
Stem Cell Reports. 17(6):1268-1278. doi: 10.1016/j.stemcr.2022.04.015.
Genome-Wide Screening Identifies Polycomb Repressive Complex 1.3 as an Essential Regulator of Human Naïve Pluripotent Cell Reprogramming
Collier AJ, Bendall A, Fabian C, Malcolm AA, Tilgner K, Semprich CI, WojdylaK, Nisi PS, Kishore K, Franklin VNR, Mirshekar-Syahkal B, D’Santos C, Plath K, Yusa K, and Rugg-Gunn PJ. (2022).
Genome-Wide Screening Identifies Polycomb Repressive Complex 1.3 as an Essential Regulator of Human Naïve Pluripotent Cell Reprogramming.
Science Advances, 8(12):eabk0013. doi: 10.1126/sciadv.abk0013.
2021
Transcriptional, Electrophysiological, and Metabolic Characterizations of hESC-Derived First and Second Heart Fields Demonstrate a Potential Role of TBX5 in Cardiomyocyte Maturation
Pezhouman A, Nguyen NB, Sercel AJ, Nguyen TL, Daraei A, Sabri S, Chapski DJ, Zheng M, Patananan AN, Ernst J, Plath K, Vondriska TM, Teitell MA, and Ardehali R. (2021).
Transcriptional, Electrophysiological, and Metabolic Characterizations of hESC-Derived First and Second Heart Fields Demonstrate a Potential Role of TBX5 in Cardiomyocyte Maturation.
Front Cell Dev Biol, 9:787684. doi: 10.3389/fcell.2021.787684.
RNA promotes the formation of spatial compartments in the nucleus
Quinodoz SA, Jachowicz JW, Bhat P, Ollikainen N, Banerjee AK, Goronzy IN, Blanco MR, Chovanec P, Chow A, Markaki Y, Thai J, Plath K, and Guttman M. (2021).
RNA promotes the formation of spatial compartments in the nucleus.
Cell, 184:5775-5790.e30. doi: 10.1016/j.cell.2021.10.014.
Xist nucleates local protein gradients to propagate silencing across the X chromosome
Markaki Y, Chong JG, Wang Y, Jacobson EC, Luong C, Tan SYX, Jachowicz JW, Strehle M, Maestrini D, Banerjee AK, Mistry BA, Dror I, Dossin F, Schöneberg J, Heard E, Guttman M, Chou T*, and Plath K*. (2021).
Xist nucleates local protein gradients to propagate silencing across the X chromosome.
Cell,184:6174-6192. https://doi.org/10.1016/j.cell.2021.10.022. *corresponding authors.
Defining the nature of human pluripotent stem cell-derived interneurons via single cell analysis. Stem Cell Reports
Allison T, Langerman J, Sabri S, Otero-Garcia M, Lund A, Wei X, Samarasinghe R, Pouladakis, D, Langerman J, Mody I, Cobos I, Novitch BN, Geschwind DH, Plath K* and Lowry WE*. (2021).
Defining the nature of human pluripotent stem cell-derived interneurons via single cell analysis. Stem Cell Reports,
16:2548-2564. doi: 10.1016/j.stemcr.2021.08.006.
The transcription factor code in iPSC reprogramming
Deng W, Jacobson EC, Collier AJ and Plath K. 2021.
The transcription factor code in iPSC reprogramming.
Curr Opin Genet Dev, 70:89-96. doi: 10.1016/j.gde.2021.06.003.
Identification of neural oscillations and epileptiform changes in human brain organoids
Samarasinghe RA, Miranda OA, Buth JE, Mitchell S, Ferando I, Watanabe M, Allison TF, Kurdian A, Fotion NN, Gandal MJ, Golshani P, Plath K, Lowry WE, Parent JM, Mody I and Novitch BG. 2021.
Identification of neural oscillations and epileptiform changes in human brain organoids.
Nature Neuroscience, 24: 1488-1500. doi: 10.1038/s41593-021-00906-5.
Divergent roles for KLF4 and TFCP2L1 in naive ground state pluripotency and human primordial germ cell development
Hancock GV, Liu W, Peretz L, Chen D, Gell JJ, Collier AJ, Zamudio JR, Plath K and Clark AT (2021).
Divergent roles for KLF4 and TFCP2L1 in naive ground state pluripotency and human primordial germ cell development.
Stem Cell Res. 55:102493. doi: 10.1016/j.scr.2021.102493.
Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition
Carraro G, Langerman J, Sabri S, Lorenzana Z, Purkayastha A, Zhang G, Konda B, Aros CJ, Calvert BA, Szymaniak A, Wilson E, Mulligan M, Bhatt P, Lu J, Vijayaraj P, Yao C, Shia DW, Lund AJ, Israely E, Rickabaugh TM, Ernst J, Mense M, Randell SH, Vladar EK, Ryan AL, Plath K*, Mahoney JE*, Stripp BR* and Gomperts BN*. (2021).
Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition.
Nature Medicine, 27:806-814. doi: 10.1038/s41591-021-01332-7. *corresponding authors.
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition
Mullen PJ, Garcia G Jr, Purkayastha A, Matulionis N, Schmid EW, Momcilovic M, Sen C, Langerman J, Ramaiah A, Shackelford DB, Damoiseaux R, French SW, Plath K, Gomperts BN, Arumugaswami V, and Christofk HR. (2021).
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition.
Nature Communications, 12:1876. doi: 10.1038/s41467-021-22166-4.
Carboxylate-Modified Magnetic Bead (CMMB)-Based Isopropanol Gradient Peptide Fractionation (CIF) Enables Rapid and Robust Off-Line Peptide Mixture Fractionation in Bottom-Up Proteomics
Deng W, Sha J, Plath K, and Wohlschlegel JA. (2021).
Carboxylate-Modified Magnetic Bead (CMMB)-Based Isopropanol Gradient Peptide Fractionation (CIF) Enables Rapid and Robust Off-Line Peptide Mixture Fractionation in Bottom-Up Proteomics.
Mol Cell Proteomics, 20:100039. doi: 10.1074/mcp.RA120.002411.
Single-cell analysis of the developing human testis reveals somatic niche cell specification and fetal germline stem cell establishment
Guo J, Sosa E, Chitiashvili T, Nie X, Rojas EJ, Oliver E; Plath K, Hotaling JM, Stukenborg JB, Clark AT, and Cairns BR. (2021).
Single-cell analysis of the developing human testis reveals somatic niche cell specification and fetal germline stem cell establishment.
Cell Stem Cell, 28:764-778.e4. doi: 10.1016/j.stem.2020.12.004.
2020
Pressure-Driven Mitochondrial Transfer Pipeline Generates Mammalian Cells of Desired Genetic Combinations and Fates
Patananan AN, Sercel AJ, Wu TH, Ahsan FM, Torres A Jr, Kennedy SAL, Vandiver A, Collier AJ, Mehrabi A, Van Lew J, Zakin L, Rodriguez N, Sixto M, Tadros W, Lazar A, Sieling PA, Nguyen TL, Dawson ER, Braas D, Golovato J, Cisneros L, Vaske C, Plath K, Rabizadeh S, Niazi KR, Chiou PY, and Teitell MA. (2020).
Pressure-Driven Mitochondrial Transfer Pipeline Generates Mammalian Cells of Desired Genetic Combinations and Fates.
Cell Reports, 29;33(13):108562.
Chromatin and Nuclear Architecture in Stem Cells
Meshorer E, Plath K. (2020).
Chromatin and Nuclear Architecture in Stem Cells.
Stem Cell Reports. 15(6):1155-1157.
Direct Exposure to SARS-CoV-2 and Cigarette Smoke Increases Infection Severity and Alters the Stem Cell-Derived Airway Repair Response
Purkayastha A, Sen C, Garcia G Jr, Langerman J, Shia DW, Meneses LK, Vijayaraj P, Durra A, Koloff CR, Freund DR, Chi J, Rickabaugh TM, Mulay A, Konda B, Sim MS, Stripp BR, Plath K*, Arumugaswami V*, and Gomperts BN*. (2020).
Direct Exposure to SARS-CoV-2 and Cigarette Smoke Increases Infection Severity and Alters the Stem Cell-Derived Airway Repair Response.
Cell Stem Cell, 27(6):869-875.e4. *corresponding authors.
Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation.
Chitiashvili T, Dror I, Kim R, Hsu FM, Chaudhari R, Pandolfi E, Chen D, Liebscher S, Schenke-Layland K, Plath K*, and Clark A*. (2020).
Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation.
Nature Cell Biology, 22(12):1436-1446. *corresponding authors.
A protein assembly mediates Xist localization and gene silencing
Pandya-Jones A, Markaki Y, Serizay J, Chitiashvili T, Mancia Leon WR, Damianov A, Chronis C, Papp B, Chen CK, McKee R, Wang XJ, Chau A, Sabri S, Leonhardt H, Zheng S, Guttman M, Black DL*, and Plath K*. (2020).
A protein assembly mediates Xist localization and gene silencing.
Nature, 587(7832):145-151. *corresponding authors.
A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells
Xi H, Langerman J, Sabri S, Chien P, Young CS, Younesi S, Hicks M, Gonzalez K, Fujiwara W, Marzi J, Liebscher S, Spencer M, Van Handel B, Evseenko D, Schenke-Layland K, Plath K*, and Pyle AD*. (2020).
A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells.
Cell Stem Cell, 27(1):181-185. *corresponding authors.
2019
Defining transcriptional signatures of human hair follicle cell states
Takahashi R, Grzenda A, Allison TF, Rawnsley J, Balin SJ, Sabri S, Plath K, and Lowry WE. (2019).
Defining transcriptional signatures of human hair follicle cell states.
Journal of Investigative Dermatology.
A Single-Cell Transcriptomic Atlas of Human Neocortical Development during Mid-gestation
Polioudakis D, de la Torre-Ubieta L, Langerman J, Elkins AG, Shi X, Stein JL, Vuong CK, Nichterwitz S, Gevorgian M, Opland CK, Lu D, Connell W, Ruzzo EK, Lowe JK, Hadzic T, Hinz FI, Sabri S, Lowry WE, Gerstein MB, Plath K, Geschwind DH.
A Single-Cell Transcriptomic Atlas of Human Neocortical Development during Mid-gestation.
Neuron. 2019 Jul 3. pii: S0896-6273(19)30561-6.
PMID:31303374
DNA methylation estimation using methylation-sensitive restriction enzyme bisulfite sequencing (MREBS
Bonora G, Rubbi L, Morselli M, Ma F, Chronis C, Plath K, Pellegrini M
DNA methylation estimation using methylation-sensitive restriction enzyme bisulfite sequencing (MREBS)
PLoS One. 2019 Apr 4;14(4):e0214368.
PMID:30946758
Promoter-Enhancer Communication Occurs Primarily within Insulated Neighborhoods
Fei Sun, Constantinos Chronis, Michael Kronenberg, Xiao-Fen Chen, Trent Su, Fides D. Lay, Kathrin Plath, Siavash K. Kurdistani, Michael F. Carey
Promoter-Enhancer Communication Occurs Primarily within Insulated Neighborhoods
Cell Stem Cell. 2019 Jan 3;24(1):138-152.e8.
PMID:30609396
The BAF and PRC2 complex subunits Dpf2 and Eed antagonistically converge on Tbx3 to control ESC differentiation.
Zhang W, Chronis C, Chen X, Zhang H, Spalinskas R, Pardo M, Chen L, Wu G, Zhu Z, Yu Y, Yu L, Choudhary J, Nichols J, Parast M, Greber B, Sahlén P, and Plath K. (2019).
The BAF and PRC2 complex subunits Dpf2 and Eed antagonistically converge on Tbx3 to control ESC differentiation.
Cell Stem Cell. 24:138-152.
2018
Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPSC reprogramming
Kai Fu, Constantinos Chronis, Abdenour Soufi, Giancarlo Bonora, Miguel Edwards, Stephen T Smale, Kenneth S. Zaret, Kathrin Plath, and Matteo Pellegrini
Comparison of reprogramming factor targets reveals both species-specific and conserved mechanisms in early iPSC reprogramming
BMC Genomics. 2018 Dec 22;19(1):956.
Reduced MEK inhibition preserves genomic stability in naïve human ES cells
Bruno Di Stefano, Mai Ueda, Shan Sabri, Justin Brumbaugh, Aaron J. Huebner, Anna Sahakyan, Kendall Clement, Katie J. Clowers, Alison R. Erickson, Keiko Shioda, Steven P. Gygi, Hongcang Gu, Toshi Shioda, Alexander Meissner, Yasuhiro Takashima, Kathrin Plath, and Konrad Hochedlinger |
Reduced MEK inhibition preserves genomic stability in naïve human ES cells
Nat Methods. 2018 Sep;15(9):732-740
Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue
Jelinek D, Flores A, Uebelhoer M, Pasque V, Plath K, Iruela-Arispe ML, Christofk HR, Lowry WE, Coller HA.
Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue.
J Vis Exp. doi: 10.3791/57760.
Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue
David Jenlinek, Aimee Flores, Melanie Uebelhoer, Vincent Pasque, Kathrin Plath, M. Luisa Iruela-Arispe, Heather R. Christofk, William E. Lowry, Hilary A. Coller
Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue
J Vis Exp. 2018 Jun 21;(136). doi: 10.3791/57760.
The Role of Xist in X-Chromosome Dosage Compensation
Sahakyan A, Yang Y and Plath K.
The Role of Xist in X-Chromosome Dosage Compensation.
Trends Cell Biology, 28: 999-1013.
Identification and Single-Cell Functional Characterization of an Endodermally Biased Pluripotent Substrate in Human Embryonic Stem Cells
Allison TF, Smith AJH, Anastassiadis K, Sloane-Stanley J, Biga V, Stavish D, Hackland J, Sabri S, Langerman J, Jones M, Plath K, Coca D, Barbaric I, Gokhale P, Andrews PW.
Identification and Single-Cell Functional Characterization of an Endodermally Biased Pluripotent Substrate in Human Embryonic Stem Cells.
Stem Cell Reports, 10: 1895-1907.
Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence
Ohashi M, Korsakova E, Allen D, Lee P, Fu K, Vargas BS, Cinkornpumin J, Salas C, Park JC, Germanguz I, Langerman J, Chronis C, Kuoy E, Tran S, Xiao X, Pellegrini M, Plath K*, and Lowry WE*.
Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence.
Stem Cell Reports, 10: 1453-1463. *corresponding authors.
X Chromosome Dosage Influences DNA Methylation Dynamics during Reprogramming to Mouse iPSCs
Pasque V, Karnik R, Chronis C, Petrella P, Langerman J, Bonora G, Song J, Vanheer L, Sadhu Dimashkie A, Meissner A, Plath K.
X Chromosome Dosage Influences DNA Methylation Dynamics during Reprogramming to Mouse iPSCs.
Stem Cell Reports, 10: 1537-1550.
Analysis of cardiomyocyte clonal expansion during mouse heart development and injury
Sereti KI, Nguyen NB, Kamran P, Zhao P, Ranjbarvaziri S, Park S, Sabri S, Engel JL, Sung K, Kulkarni RP, Ding Y, Hsiai TK, Plath K, Ernst J, Sahoo D, Mikkola HKA, Iruela-Arispe ML, Ardehali R.
Analysis of cardiomyocyte clonal expansion during mouse heart development and injury.
Nature Communication, 9 :754.
High-Throughput Screening of a Luciferase Reporter of Gene Silencing on the Inactive X Chromosome
Keegan A, Plath K, Damoiseaux R.
High-Throughput Screening of a Luciferase Reporter of Gene Silencing on the Inactive X Chromosome.
Methods Mol Biol, 1755: 75-87.
2017
Regulation of X-chromosome dosage compensation in human: mechanisms and model systems
Sahakyan A, Plath K, Rougeulle C.
Regulation of X-chromosome dosage compensation in human: mechanisms and model systems.
Philos Trans R Soc Lond B Biol Sci. 2017 Nov 5;372(1733). pii: 20160363. doi: 10.1098/rstb.2016.0363. Review.
Epigenetic resetting of human pluripotency
Guo G, von Meyenn F, Rostovskaya M, Clarke J, Dietmann S, Baker D, Sahakyan A, Myers S, Bertone P, Reik W, Plath K, Smith A.
Epigenetic resetting of human pluripotency.
2017 Aug 1;144(15):2748-2763. doi: 10.1242/dev.146811.
Cbx3 maintains lineage specificity during neural differentiation
Huang C, Su T, Xue Y, Cheng C, Lay F, McKee R, Li M., Vashisht A, Wohlschlegel J, Novitch B, Plath K, Kurdistani S, Carey M
Cbx3 maintains lineage specificity during neural differentiation
Genes Dev. 2017 31: 241-246. 10.1101/gad.292169.116
Cooperating Binding of Transcription Factors Orchestrates Reprogramming
Chronis C, Fiziev P, Papp B, Butz S, Bonora G, Sabri S, Ernst J, Plath K
Cooperating Binding of Transcription Factors Orchestrates Reprogramming
Cell. 2017 Jan 19; 168; 1-18. doi: 10.1016/j.cell.2016.12.016
2016
Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation
Sahakyan A, Kim R, Chronis C, Sabri S, Bonora G, Theunissen T, Kuoy E, Langerman J, Clark AT, Jaenisch R, Plath K.
Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation
Cell Stem Cell. 2016 Dec 15; 20: 1-15. doi: 10.1016/j.stem.2016.10.006
Human Embryonic Stem Cells Do Not Change Their X Inactivation Status during Differentiation
Patel S, Bonora G, Sahakyan A, Kim R, Chronis C, Langerman J, Fitz-Gibbon S, Rubbi L, Skelton RJP, Ardehali R, Pellegrini M, Lowry WE, Clark AT, Plath K.
Human Embryonic Stem Cells Do Not Change Their X Inactivation Status during Differentiation
Cell Reports. 2016 Dec 15; 18:1-14. doi: 10.1016/j.celrep.2016.11.054
Glycolytic Metabolism Plays a functional Role in Regulating Human Pluripotent Stem Cell State
Gu W, Gaeta X, Sahakyan A, Chan AB, Hong CS, Kim R, Braas D, Plath K, Lowry WE, Christofk HR.
Glycolytic Metabolism Plays a functional Role in Regulating Human Pluripotent Stem Cell State.
Cell Stem Cell. 2016 Oct 6; 19(4):476-490. doi: 10.1016/j.stem.2016.08.008
Transcriptome Encyclopedia of Early Human Development
Sahakyan A, Plath K.
Transcriptome Encyclopedia of Early Human Development
Cell. 2016 May 5; 165(4):777-9. doi: 10.1016/j.cell.2016.04.042
The Inc between 3D Chromatin Structure and X Chromosome Inactivation
Pandya-Jones A, Plath K.
The Inc between 3D Chromatin Structure and X Chromosome Inactivation.
Semin Cell Dev Biol. 2016 Apr 5. pii: S1084-9521(16)30087-8. doi: 10.1016/j.semcdb.2016.04.002.
Naive Human Pluripotent Cells Feature a Methylation Landscape Devoid of Blastocyst or Germline Memory
Pastor WA, Chen D, Liu W, Kim R, Sahakyan A, Lukianchikov A, Plath K, Jacobsen SE, Clark AT
Naive Human Pluripotent Cells Feature a Methylation Landscape Devoid of Blastocyst or Germline Memory
Cell Stem Cell. 2016 Feb 2. pii: S1934-5909(16)00020-5. doi: 10.1016/j.stem.2016.01.019
2015
X chromosome reactivation in reprogramming and in development
Pasque V, Plath K.
X chromosome reactivation in reprogramming and in development
Curr Opin Cell Biol. 2015 Dec; 37: 75-83. doi: 10.1016/j.ceb.2015.10.006. Epub 2015 Nov 11.
A high-throughput screen of inactive X chromosome reactivation identifies the enhancement of DNA demethylation by 5-aza-2?-dC upon inhibition of ribonucleotide reductase
Minkovsky A, Sahakyan A, Bonora G, Damoiseaux R, Dimitrova E, Rubbi L, Pellegrini M, Radu C, Plath K.
A high-throughput screen of inactive X chromosome reactivation identifies the enhancement of DNA demethylation by 5-aza-2?-dC upon inhibition of ribonucleotide reductase.
Epigenetics & Chromatin. 2015, 8:42.
The Xist lncRNA directly interacts with SHARP to silence transcription through HDAC3
McHugh CA, Chen CK, Chow A, Surka CF, Tran C, McDonel P, Pandya-Jones A, Blanco MR, Burghard C, Moradian A, Sweredoski MJ, Shishkin AA, Su J, Lander ES, Hess S, Plath K, and Guttman M
The Xist lncRNA directly interacts with SHARP to silence transcription through HDAC3
Nature doi:10.1038/nature14443
2014
X Chromosome Reactivation Dynamics Reveal Stages of Reprogramming to Pluripotency
Pasque V*, Tchieu J*, Karnik R, Uyeda M, Sadhu Dimashkie A, Case D, Papp B, Bonora G, Patel S, Ho R, Schmidt R, McKee R, Sado T, Tada T, Meissner A, Plath K.
X Chromosome Reactivation Dynamics Reveal Stages of Reprogramming to Pluripotency
Cell. 2014 Dec 18; 159(7); 1681-97. *authors contributed equally
A mechanistic link between gene regulation and genome architecture in mammalian development
Bonora G, Plath K**, Denholtz M**.
A mechanistic link between gene regulation and genome architecture in mammalian development.
Curr Opin Genet Dev. 2014 Aug;27:92-101.** Corresponding authors.
The Mbd1-Atf7ip-Setdb1 pathway contributes to the maintenance of X chromosome inactivation
Minkovsky A, Sahakyan A, Rankin-Gee E, Bonora G, Patel S, Plath K.
The Mbd1-Atf7ip-Setdb1 pathway contributes to the maintenance of X chromosome inactivation.
Epigenetics & Chromatin. 2014 Jun 26;7:12.
2013
Long-range chromatin contacts in embryonic stem cells reveal a role for pluripotency factors and polycomb proteins in genome organization
Denholtz M*, Bonora G*, Chronis C, Splinter E, de Laat W, Ernst J, Pellegrini M**, Plath K**.
Long-range chromatin contacts in embryonic stem cells reveal a role for pluripotency factors and polycomb proteins in genome organization.
Cell Stem Cell. 2013 Nov 7;13(5):602-16. *authors contributed equally; ** Corresponding authors.
The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome
Engreitz JM, Pandya-Jones A, McDonel P, Shishkin A, Sirokman K, Surka C, Kadri S, Xing J, Goren A, Lander ES**, Plath K**, Guttman M**.
The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome.
Science. 2013 Aug 16;341(6147):1237973.** Corresponding authors. (also see Perspective in Science)
Initial Characterization of Histone H3 Serine 10 O-Acetylation
Britton, L.P., Newhart, A., Bhanu, N.V., Sridharan, R., Gonzales-Cope, M., Plath, K., Janicki, S.M., and Garcia, B.A.
Initial Characterization of Histone H3 Serine 10 O-Acetylation
Epigenetics. 2013 8:1101-1113.
A new route to human embryonic stem cells
Trounson A, Daley GQ, Pasque V, Plath K.
A new route to human embryonic stem cells.
Nature Medicine. 2013 19(7):820-821.
Stage-specific regulation of reprogramming to induced pluripotent stem cells by Wnt signaling and T cell factor proteins.
Ho R*, Papp B*, Hoffman JA, Merrill BJ**, Plath K**.
Stage-specific regulation of reprogramming to induced pluripotent stem cells by Wnt signaling and T cell factor proteins.
Cell Rep. 2013 Jun 27;3(6):2113-26. *authors contributed equally; ** Corresponding authors.
Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1? in reprogramming to pluripotency
Sridharan R, Gonzales-Cope M*, Chronis C*, Bonora G, McKee R, Huang C, Patel S, Lopez D, Mishra N, Pellegrini M, Carey M, Garcia BA**, Plath K**.
Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1? in reprogramming to pluripotency.
Nat Cell Biol. 2013 Jul;15(7):872-82. *authors contributed equally; ** Corresponding authors.
The pluripotency factor-bound intron 1 of Xist is dispensable for X chromosome inactivation and reactivation in vitro and in vivo
Minkovsky A, Barakat TS, Sellami N, Chin MH, Gunhanlar N, Gribnau J, Plath K.
The pluripotency factor-bound intron 1 of Xist is dispensable for X chromosome inactivation and reactivation in vitro and in vivo.
Cell Rep. 2013 Mar 28;3(3):905-18.
Epigenetics of Reprogramming to Induced Pluripotency
Papp, B. and Plath, K.
Epigenetics of Reprogramming to Induced Pluripotency.
Cell. 2013 152:1324-1343.
2012
Pluripotency in 3D: genome organization in pluripotent cells
Denholtz M, Plath K.
Pluripotency in 3D: genome organization in pluripotent cells.
Curr Opin Cell Biol. 2012 Dec;24(6):793-801.
Mediator and SAGA have distinct roles in Pol II preinitiation complex assembly and function
Chen, X.F., Lehmann, L., Lin, J.J., Vashisht, A., Schmidt, R., Ferrari, R., Huang, C., McKee, R., Mosley, A., Plath, K., Kurdistani, S.K., Wohlschlegel, J., and Carey, M.
Mediator and SAGA have distinct roles in Pol II preinitiation complex assembly and function.
Cell Reports. 2012 2:1061-1067.
Pluripotency re-centered around Esrrb
Papp B, Plath K.
Pluripotency re-centered around Esrrb.
EMBO J. 2012, Nov 14;31(22):4255-7.
Stem cells in the land of the rising sun: ISSCR 2012.
Plath, K., Srivastava, D., Alvarez-Buylla, A., Tanaka, E.M., Kriegstein, A.R.
Stem cells in the land of the rising sun: ISSCR 2012.
Cell Stem Cell. 2012, 11(5):607-614.
The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation
Schmidt R, Plath K.
The roles of the reprogramming factors Oct4, Sox2 and Klf4 in resetting the somatic cell epigenome during induced pluripotent stem cell generation.
Genome Biol. 2012, Oct 22;13(10):251.
Cell reprogramming
Pera, M.F., and Plath, K.
Cell reprogramming.
Current Opinion Genet Dev. 2012, 22(5):401-402.
Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells
Nsair, A., Schenke-Layland, K., Van Handel, B., Evseenko, D., Kahn, M., Zhao, P., Mendelis, J., Heydarkhan, S., Awaji, O., Vottler, M., Geist, S., Chyu, J., Gago-Lopez, N., Crooks, G.M., Plath, K., Goldhaber, J., Mikkola, H.K., and MacLellan, W.R.
Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells.
Plos One. 2012, 7(10):e45603.
Derivation of new human embryonic stem cell lines reveals rapid epigenetic progression in vitro that can be prevented by chemical modification of chromatin
Diaz-Perez, S.V., Kim, R., Li, Z., Marquez, V.E., Patel, S., Plath, K., Clark, A.T.
Derivation of new human embryonic stem cell lines reveals rapid epigenetic progression in vitro that can be prevented by chemical modification of chromatin.
Hum Mol Genet. 2012, 21(4):751-764.
From skin biopsy to neurons through a pluripotent intermediate under Good Manufacturing Practice protocols.
Karumbayaram, S., Lee, P., Azghadi, S.F., Cooper, A.R., Patterson, M., Kohn, D.B., Pyle, A., Clark, A., Byrne, J., Zack, J.A., Plath, K., and Lowry, W.E.
From skin biopsy to neurons through a pluripotent intermediate under Good Manufacturing Practice protocols.
Stem Cells Transl Med. 2012, 1(1):36-43.
Concise review: Pluripotency and the transcriptional inactivation of the female Mammalian X chromosome
Minkovsky A, Patel S, Plath K.
Concise review: Pluripotency and the transcriptional inactivation of the female Mammalian X chromosome.
Stem Cells. 2012, Jan;30(1):48-54.
2011
Mediator coordinates PIC assembly with recruitment of CHD1
Lin JJ, Lehmann LW, Bonora G, Sridharan R, Vashisht AA, Tran N, Plath K, Wohlschlegel JA, Carey M.
Mediator coordinates PIC assembly with recruitment of CHD1.
Genes Dev. 2011 Oct 15;25(20):2198-209.
Highly efficient large-scale lentiviral vector concentration by tandem tangential flow filtration
Cooper, A.R., Patel, S., Senadheera, S., Plath, K., Kohn, D.B., and Hollis, R.P.
Highly efficient large-scale lentiviral vector concentration by tandem tangential flow filtration.
J Virol Methods. 2011 177:1-9.
Small RNAs loom large during reprogramming
Sridharan R, Plath K.
Small RNAs loom large during reprogramming.
Cell Stem Cell. 2011 Jun 3;8(6):599-601.
Progress in understanding reprogramming to the induced pluripotent state
Plath, K. and Lowry, W.E.
Progress in understanding reprogramming to the induced pluripotent state.
Nature Reviews Genetics. 2011 12:253-265.
Reprogramming to pluripotency: stepwise resetting of the epigenetic landscape
Papp, B. and Plath, K.
Reprogramming to pluripotency: stepwise resetting of the epigenetic landscape.
Cell Research. 2011 21:486-501.
2010
Mechanistic insights into reprogramming to induced pluripotency
Ho R*, Chronis C*, Plath K.
Mechanistic insights into reprogramming to induced pluripotency.
J Cell Physiol. 2010 Oct 13. * Authors contributed equally to this work.
Identification and classification of chromosomal aberrations in human induced pluripotent stem cells
Mayshar Y, Ben-David U, Lavon N, Biancotti JC, Yakir B, Clark AT, Plath K, Lowry WE, Benvenisty N.
Identification and classification of chromosomal aberrations in human induced pluripotent stem cells.
Cell Stem Cell. 2010 Oct 8;7(4):521-31.
Identification of Context-Dependent Motifs by Contrasting ChIP Binding Data
Mason MJ, Plath K, Zhou Q.
Identification of Context-Dependent Motifs by Contrasting ChIP Binding Data.
Bioinformatics. 2010 Nov 15;26(22):2826-32.
Female human iPSCs retain an inactive X chromosome
Tchieu J*, Kuoy E*, Chin MH, Trinh H, Patterson M, Sherman SP, Aimiuwu O, Lindgren A, Hakimian S, Zack JA, Clark AT, Pyle AD, Lowry WE, Plath K.
Female human iPSCs retain an inactive X chromosome.
Cell Stem Cell. 2010 Sep 3;7(3):329-42. * Authors contributed equally to this work.
Molecular analyses of human induced pluripotent stem cells and embryonic stem cells
Chin MH, Pellegrini M, Plath K**, Lowry WE**.
Molecular analyses of human induced pluripotent stem cells and embryonic stem cells.
Cell Stem Cell. 2010 Aug 6;7(2):263-9. ** Corresponding authors.
2009
Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells
Xu J, Watts JA, Pope SD, Gadue P, Kamps M, Plath K, Zaret KS, Smale ST.
Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells.
Genes Dev. 2009 Dec 15;23(24):2824-38.
Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis
Hiratani I, Ryba T, Itoh M, Rathjen J, Kulik M, Papp B, Fussner E, Bazett-Jones DP, Plath K, Dalton S, Rathjen PD, Gilbert DM.
Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis.
Genes Dev. 2009 Dec 15;23(24):2824-38.
Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells
Mason MJ, Fan G, Plath K, Zhou Q, Horvath S.
Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells.
BMC Genomics. 2009 Jul 20;10:327.
Chd1 regulates open chromatin and pluripotency of embryonic stem cells
Gaspar-Maia A, Alajem A, Polesso F, Sridharan R, Mason MJ, Heidersbach A, Ramalho-Santos J, McManus MT, Plath K, Meshorer E, Ramalho-Santos M.
Chd1 regulates open chromatin and pluripotency of embryonic stem cells.
Nature. 2009 Aug 13;460(7257):863-8.
Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures.
Chin MH, Mason MJ, Xie W, Volinia S, Singer M, Peterson C, Ambartsumyan G, Aimiuwu O, Richter L, Zhang J, Khvorostov I, Ott V, Grunstein M, Lavon N, Benvenisty N, Croce CM, Clark AT, Baxter T, Pyle AD, Teitell MA, Pelegrini M, Plath K**, Lowry WE**.
Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures.
Cell Stem Cell. 2009 Jul 2;5(1):111-23. ** Corresponding authors.
Broader implications of defining standards for the pluripotency of iPSCs
Daley GQ, Lensch MW, Jaenisch R, Meissner A, Plath K, Yamanaka S.
Broader implications of defining standards for the pluripotency of iPSCs.
Cell Stem Cell. 2009 Mar 6;4(3):200-1
Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells
Xie W, Song C, Young NL, Sperling AS, Xu F, Sridharan R, Conway AE, Garcia BA, Plath K, Clark AT, Grunstein M.
Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells.
Mol Cell. 2009 Feb 27;33(4):417-27.
Directed differentiation of human-induced pluripotent stem cells generates active motor neurons
Karumbayaram S, Novitch BG, Patterson M, Umbach JA, Richter L, Lindgren A, Conway AE, Clark AT, Goldman SA, Plath K, Wiedau-Pazos M, Kornblum HI, Lowry WE.
Directed differentiation of human-induced pluripotent stem cells generates active motor neurons.
Stem Cells. 2009 Apr;27(4):806-11.
Post-translational regulation of Oct4 transcriptional activity
Saxe JP, Tomilin A, Schöler HR, Plath K, Huang J.
Post-translational regulation of Oct4 transcriptional activity.
PLoS ONE. 2009;4(2):e4467.
Epigenetic reprogramming and induced pluripotency
Hochedlinger K, Plath K.
Epigenetic reprogramming and induced pluripotency.
Development. 2009 Feb;136(4):509-23.
X chromosome inactivation in the absence of Dicer
Kanellopoulou C, Muljo SA, Dimitrov SD, Chen X, Colin C, Plath K**, Livingston DM**.
X chromosome inactivation in the absence of Dicer.
Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1122-7. ** Corresponding authors.
Role of the murine reprogramming factors in inducing pluripotency
Sridharan R*, Tchieu J*, Mason MJ*, Yachechko R, Kuoy E, Horvath S, Zhou Q and Plath K.
Role of the murine reprogramming factors in inducing pluripotency.
Cell 2009 Jan 23;136(2):364-77. * Authors contributed equally to this work.
Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells
Park TS, Galic Z, Conway AE, Lindgren A, van Handel BJ, Magnusson M, Richter L, Teitell MA, Mikkola HK, Lowry WE, Plath K, Clark AT.
Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells.
Stem Cells. 2009 Apr;27(4):783-95.
2008
The many ways to make an iPS cell
Lowry WE, Plath K.
The many ways to make an iPS cell.
Nat Biotechnol. 2008 Nov;26(11):1246-8.
Reprogrammed fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages
Schenke-Layland K, Rhodes K, Angelis E, Butylkova Y, Heydarkhan-Hagvall S, Gekas C, Zhang R, Goldhaber J, Mikkola HK, Plath K and MacLellan WR.
Reprogrammed fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages.
Stem Cells 2008 Jun;26(6):1537-46.
Illuminating the black box of reprogramming
Sridharan, R. and Plath, K.
Illuminating the black box of reprogramming.
Cell Stem Cell. 2008 2:295-297
Generation of human induced pluripotent stem cells from dermal fibroblasts
Lowry WE**, Richter L*, Yachechko R*, Pyle AD, Tchieu J, Sridharan R, Clark AT, Plath K**.
Generation of human induced pluripotent stem cells from dermal fibroblasts.
Proc Natl Acad Sci USA. 2008 Feb 26;105(8):2883-8. * Both authors contributed equally to this work. ** Corresponding authors.
2007
The histone domain of macroH2A1 contains several dispersed elements that are each sufficient to direct enrichment on the inactive X chromosome.
Nusinow DA, Sharp JA, Morris A, Salas S, Plath K, Panning B.
The histone domain of macroH2A1 contains several dispersed elements that are each sufficient to direct enrichment on the inactive X chromosome.
J Mol Biol. 2007 Aug 3;271(1):11-8.
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution
Maherali N*, Sridharan R*, Xie W, Utikal J, Eminli S, Arnold K, Stadtfeld K, Yachechko R, Tchieu J, Jaenisch R, Plath K**, Hochedlinger K**.
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution.
Cell Stem Cell 2007 June 7;1(1):55-70 * Authors contributed equally to this work. ** Corresponding authors
2006
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, Fry B, Meissner A, Wernig M, Plath K, Jaenisch R, Waqschal A, Feil R, Schreiber SL, Lander ES.
A bivalent chromatin structure marks key developmental genes in embryonic stem cells.
Cell 2006, Apr 21;125(2):315-26
Polycomb complexes repress developmental regulators in murine embryonic stem cells
Boyer LA*, Plath K*, Zeitlinger J, Brambrink T, Medeiros L, Lee TI, Levine SS, Wernig M, Tajonar A, Ray MK, Bell GW, Otte AP, Vidal M, Gifford DK, Young RA and Jaenisch R.
Polycomb complexes repress developmental regulators in murine embryonic stem cells.
Nature 2006, May 18;441(7091):349-53 * Authors contributed equally to this work.
Mapping post-translational modifications of the histone variant MacroH2A1 using tandem mass spectrometry
Chu F, Nusinow DA, Chalkley RJ, Plath K, Panning B, Burlingame AL.
Mapping post-translational modifications of the histone variant MacroH2A1 using tandem mass spectrometry.
Mol Cell Proteomics 2006, Jan;5(1):194-203.
An efficient method to generate single-copy transgenic mice by site specific integrationin embryonic stem cells
Beard C, Hochedlinger K, Plath K, Wutz A and Jaenisch R.
An efficient method to generate single-copy transgenic mice by site specific integrationin embryonic stem cells.
Genesis 2006, Jan;44(1):23-8.
2005
Developmental regulation of Suz12 localization
de la Cruz CC, Fang J, Plath K, Worringer KA, Nusinow DA, Zhang Y and Panning B.
Developmental regulation of Suz12 localization.
Chromosoma 2005;114(3):183-92.
2004
Developmentally regulated alterations in polycomb repressive complex 1 proteins on the inactive X chromosome
Plath K, Talbot D, Hamer KM, Otte AP, Yang TP, Jaenisch R and Panning B.
Developmentally regulated alterations in polycomb repressive complex 1 proteins on the inactive X chromosome.
J. Cell Biol. 2004;167(6):1025-35.
Interactions between Sec-complex and perpro-a-factor during posttranslational protein transport into the ER
Plath K, Wilkinson BM, Stirling CJ and Rapoport TA.
Interactions between Sec-complex and perpro-a-factor during posttranslational protein transport into the ER.
Mol. Biol. Cell, 2004;15(1):1-10.
2003
Role of histone H3 lysine 27 methylation in X inactivation
Plath K, Fang J, Mlynarczyk-Evans SK, Cao R, Worringer KA, Wang H, de la Cruz CC, Otte AP, Panning B and Zhang Y.
Role of histone H3 lysine 27 methylation in X inactivation.
Science 2003;300(1):131-135.
2002
Xist RNA and the mechanism of X chromosome inactivation
Plath K, Mlynarczyk-Evans SK, Nusinow DA and Panning B.
Xist RNA and the mechanism of X chromosome inactivation.
Annu. Rev. Genet. 2002;36(1):233-78.
Spontaneous release of cytosolic proteins from posttranslational substrates before their transport into the endoplasmic reticulum
Plath K, Rapoport TA.
Spontaneous release of cytosolic proteins from posttranslational substrates before their transport into the endoplasmic reticulum.
J. Cell Biol. 2000;151(1):167-178.
2000
The structure of ribosome-channel complexes engaged in protein translocation
Menetret JF, Neuhof A, Morgan DG, Plath K, Radermacher M, Rapoport TA and Akey CW.
The structure of ribosome-channel complexes engaged in protein translocation.
Mol. Cell. 2000;6:1219-1232.
Protein transport into the endoplasmic reticulum
Plath K.
Protein transport into the endoplasmic reticulum.
Biospektrum. 2000;6:466-467.
1999
Posttranslational protein translocations across the membrane of the endoplasmic reticulum
Rapoport TA, Matlack KES, Plath K, Misselwitz B and Staeck O.
Posttranslational protein translocations across the membrane of the endoplasmic reticulum.
Biol. Chem 1999;380:1143-1150.
BiP acts as a molecular ratchet during posttranslational transport of prepro-factor across the ER membrane.
Matlack KES, Misselwitz B, Plath K and Rapoport TA.
BiP acts as a molecular ratchet during posttranslational transport of prepro-factor across the ER membrane.
Cell 1999;97:553-564.
1998
Signal sequence recognition in posttranslational protein transport across the yeast ER membrane
Plath, K., Mothes, W., Wilkinson, B.M., Stirling, C.J., Rapoport, T.A.
Signal sequence recognition in posttranslational protein transport across the yeast ER membrane.
Cell 1998;94:795-807.
1997
Protein transport by purified yeast Sec complex and Kar2p without membranes.
Matlack, K.E., Plath, K., Misselwitz, B., Rapoport, T.A.
Protein transport by purified yeast Sec complex and Kar2p without membranes.
Science 1997; 277:938-941.
1996
Oligomeric rings of the Sec61p complex induced by ligands required for protein translocation
Hanein D, Matlack KE, Jungnickel B, Plath K, Kalies KU, Miller KR, Rapoport TA and Akey CW.
Oligomeric rings of the Sec61p complex induced by ligands required for protein translocation.
Cell 1996;87:721-732.
A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S. cerevisiae.
Finke K*, Plath K*, Panzer S, Prehn S, Rapoport TA, Hartmann and Sommer T.
A second trimeric complex containing homologs of the Sec61p complex functions in protein transport across the ER membrane of S. cerevisiae.
EMBO J. 1996;15:1482-1494. * Authors contributed equally to this work.
1995
Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif
Engel K, Schultz H, Martin F, Kotlyarov A, Plath K, Hahn M, Heinemann U and Gaestel M.
Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif.
J. Biol. Chem. 1995;270:27213-21.
1994
Characterization of the proline-rich region of mouse MAPKAP kinase 2: influence on catalytic properties and binding to the c-abl SH3 domain in vitro
Plath K, Engel K, Schwedersky G and Gaestel M.
Characterization of the proline-rich region of mouse MAPKAP kinase 2: influence on catalytic properties and binding to the c-abl SH3 domain in vitro.
Biochem. Biophys. Res. Commun. 1994;203:1188-1194.
1993
The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain
Engel K, Plath K and Gaestel M.
The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain.
FEBS Lett. 1993;336:143-147.